In the world of nutrition, people have known for a long time that the sprouts of cruciferous vegetables and legumes are powerhouses of valuable nutrients. But with a growing body of evidence supporting a cluster of impressive health benefits, the humble broccoli sprout has come to the forefront – and clinicians and researchers in nutrition are finding new ways to harness its unique power.

The secret to the health benefits of this remarkable food lies in the bioactive compound sulforaphane, which is generated in high concentrations when broccoli sprouts are consumed. Over a thousand published studies have identified sulforaphane as one of the most potent food-derived molecules of our era, and that some truly remarkable health benefits that can be accessed through its main source, broccoli sprouts.

The bioactives from broccoli sprouts can influence many of the genes that govern cellular function, ‘turning up’the ones whose expression is beneficial in maintaining health, and ‘turning down’ the ones that result in maladaptive outcomes.

1. Support for healthy aging

Aging is a complex process, with genetic and environmental influences both playing major roles in the individual’s experience of their health throughout their lifespan. But through vigorous research in nutrigenomics, it’s become evident that the key to maintaining the health of the aging human body is through supporting its cells to maintain their normal activity. This helps facilitate the defence of normal cellular function against external threats to health that are encountered every day.

While it’s not possible to prevent aging, it’s theoretically possible to support the health and wellbeing of people as they age, reducing the incidence of factors that contribute to a decreased quality of life—the sulforaphane derived from broccoli sprouts is an important key.

Healthy middle aged couple


The ability to support cell defences is the key to any preventive intervention—and this is true for all chronic diseases. Sulforaphane is a potent activator of the cellular ‘switch’ Nrf2, described as the ‘master regulator’ of cell defences.

2. Defence against disease

Nrf2 influences over 2000 genes associated with protecting the cells and increases the cell’s production of many different defensive proteins. Nrf2 can regulate many of the processes that form the basis of disease. When Nrf2 is activated, a large number of protective and detoxification cellular enzymes are upregulated; these are literally millions of times more capable of destroying free radicals than are vitamin and other food-derived antioxidants.

The cell’s own protective defences effectively inhibit inflammation-producing pathways and can safely metabolise oestrogens, other hormones and environmental toxins to prevent the formation of mutagenic (cancer producing) DNA adducts. In essence, sulforaphane has the potential to block carcinogen-activating enzymes; it is for this reason that sulforaphane is considered to have the potential to act asa potent, preventive, cancer-preventive compound.

Sulforaphane’s strength lies not only in its potency but also in its second benefit: bio-availability. Approximately 80% of what is ingested finds its way into the cells; this is in stark contrast to many other common supplements like curcumin, green tea polyphenols, and resveratrol, which are only around 1% bio-available. Essentially, sulforaphane’s potency can be accessed easily by the body, and it can more readily enter the cells of the target tissue or organ at a dose that’s clinically significant. It’s likely that the research will soon show more exciting results for prevention and treatment of many common diseases.


Defence against disease

The 2014 study was published in the Proceedings of the New York Academy of Sciences and detailed a clinical trial that was conducted over 18 weeks, where significant changes in behavioural markers were observed in young adults diagnosed with autism.

3. Early evidence for sulforaphane’s potential to favourably impact autism

One of the most promising and remarkable studies involving sulforaphane revealed its potential in treating Autism Spectrum Disorder (ASD).

There have been several other studies on the influence of sulforaphane in treating ASD and more evidence is being gathered all the time in support of its abilities—which Singh et al. (2014) identify as ‘protecting aerobic cells against oxidative stress, inflammation, and DNA-damage’, all of which are prominent and possibly mechanistic characteristics of ASD. ASD is a poorly understood condition with an enormous impact on the quality of life of its sufferers—but sulforaphane from broccoli sprouts could one day be regarded as an important contributor to drugless treatment.

Child with Autism Spectrum Disorder (ASD)

Some of the most common and potentially fatal afflictions in our society stem from problems with the cardiovascular system. Genetics, lifestyle and aging all influence the health of the cardiovascular system, leading to problems with the heart and blood vessels, which in turn impact on other body systems to reduce the quality of life of sufferers as they age..

4. Potential support for the cardiovascular system

Sulforaphane influences the production of protective enzymes to support the blood vessels, as well as supporting the immune system to reduce inflammatory and oxidative molecules that cause cell damage. It’s been shown in some studies to reverse damage to blood vessels by addressing endothelial dysfunction which can lead to calcification of the smooth muscle lining blood vessels and formation of arterial plaque in the heart and vessels.

These signs are linked to cardiovascular diseases including heart attack and stroke; high blood pressure is often an accompanying sign that the health of the blood vessels is not normal. When blood vessel function is abnormal, kidney disease and type 2 diabetes will sometimes follow. This is why bioactive molecules like sulforaphane can benefit a range of health abnormalities by targeting the function of the lining of the blood vessels, the endothelium.

Young healthy couple running

A common recommendation in nutritional medicine is to‘treat the gut first’. Gut health influences many of the body’s other processes and is one of the primary causes of malabsorption of nutrients,setting the scene for the development of other abnormalities.

5. Improving gut health

One of the most promising and remarkable studies involving sulforaphane revealed its potential in treating Autism Spectrum Disorder (ASD).

For an individual to enjoy optimal health, cells lining the gastrointestinal tract (the enterocytes) need to function at their peak; sulforaphane helps these cells to function more efficiently. The common stomach infection, Helicobacter Pylori, can lead to the development of severe inflammation and possibly to stomach ulcers. Sulforaphanehas been shown to destroy the H. Pylori bacterium, at the same time controlling inflammation in the stomach lining. In this way, sulforaphane supports one of the most important body systems.

Large round belly

EnduraCell products

How can EnduraCell have so many different properties?

Optimising cell function should beat the core of any successful therapeutic intervention. Sulforaphane is both highly potent and highly bio-available, giving it the ability to activate the endogenous defence mechanisms of practically every cell in the body. This makes it an ideal foundation for any patient wishing to prevent or treat a range of health disorders.

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What makes EnduraCell superior?

EnduraCell is an enzyme-active 100% whole broccoli sprout powder, optimised for its sulforaphane yield. As a science-based company, Cell-Logic has developed its unique manufacturing technology to produce EnduraCell, which yields the highest sulforaphane concentration of any broccoli sprout supplement currently available. When compared with other whole broccoli sprout powders, one gram of EnduraCell yields around 3-4 times greater sulforaphane. This provides a manageable dose, which is capable of matching the large doses of fresh sprouts and sprout powder used in a number of clinical trials.

EnduraCell is a nutraceutical-grade, not a food-grade product. As such, in every single batch of our broccoli sprout raw material, we test at many steps throughout its production from seed through fresh sprout, to dried sprout and finally to finely milled powder. 

It is our in-depth knowledge of the physiology of the broccoli plant that enables us to produce the highest sulforaphane-yielding 100% broccoli sprout product anywhere in the world. For this reason, clinicians across the globe recommend EnduraCell for their patients, knowing that the product is supported by solid science and ongoing research.

As a core supplement to assist in maintaining health and vitality and in preventing illness, consider the EnduraCell family of formulations as your nutrigenomically active supplements of choice – they’re available from leading clinicians and online from Cell-Logic.


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2021-07-27 12:27:21